Volumetric MRI Evaluation of Pituitary Gland in North Indian Subjects with Non-diseased Pituitary: Setting the Standards for Normative Data

Introduction The pituitary gland, also called the master was first described by a Belgian scientist Andreas Vesalius in 1543. Pituitary gland is engine of normal human physiology and its size volume changes normally during various physiological stages as well pathological processes, so it becomes imperative to have reference value for particular population differentiate gland. It tiny endocrine found sella turcica (meaning Turkish Saddle) sphenoid. Our study designed obtain standardized values volumes among North Indian analyze potential diagnostic volumetric variation with respect age gender. measured using thin section three dimensional (3D) magnetic resonance imaging (MRI) thickness 1 mm. Methods conducted between 2018-21 on patients non-diseased performing T1-multiplanar sequence calculating Di chiro & Nelson formula. MRI performed Siemens 3 Tesla scanner unit. High resolution Multiplanar-T1 Weighted images were obtained following parameters: Slice thickness: mm, Acquisition plane: Sagittal Coronal TR 1180 MS, TE 4.4 Flip angle: 15 degrees, Matrix size: 256 × 256, FOV: 24 cm. Volume = 0.52 Depth Plane Height Width Results There 152 included study. mean participants 43.50 years. Age group 20-30 years comprised maximum number patient’s .The overall 277.96 mm3 males 267.74 while females 288.74 mm3. largest 401.94 369.86 respectively 10–20-year 319.18 360.49 group. Beyond 70 children less than 10 showed smallest pituitary. Mean depth 9.40 width 8.81